Israeli Prime Minister Benjamin Netanyahu said Saturday that there are "growing signs” that Iran’s Supreme Leader Ali Khamenei is “no more,” following sweeping Israeli strikes on senior Iranian political and military figures.

In a video address to the Israeli public, Netanyahu said Israel had eliminated top commanders of the Islamic Revolutionary Guard Corps, senior regime officials and leading nuclear scientists in strikes carried out earlier in the day.

“This morning we struck the heads of the terror regime,” he said, adding that Israel would in the coming days hit “thousands of targets” linked to Tehran’s leadership and security apparatus.

Netanyahu said the operation against Iran would continue “for as long as necessary” and cautioned that “stamina is required.” He framed the campaign as a decisive effort to “fundamentally change” the strategic reality in which, he said, Iran was advancing toward a nuclear weapon that would dramatically increase its ability to threaten Israel and other countries in the region.

“This war will lead to peace. True peace,” Netanyahu said.

He also thanked U.S. President Donald Trump for what he called his “historic leadership,” praising him as “a leader who keeps his word.”

Turning directly to the Iranian people, Netanyahu urged them to seize what he described as a rare opportunity to overthrow their rulers.

“Don’t miss this opportunity. This is a once-in-a-generation moment,” he said in Hebrew, before switching to English: “Help has arrived.”

He called on Iranians to “flood the streets” when the time comes and “finish the job” of bringing down what he described as a “regime of horrors” that has embittered their lives. Israel’s actions, he said, were intended to create the conditions for the Iranian people “to free themselves from the chains of dictatorship.”

Israeli media reported that the initial wave of strikes targeted roughly 30 senior Iranian leaders and military commanders, including Khamenei. Israeli officials have been widely quoted as saying the supreme leader was likely killed, though there has been no formal confirmation from the Israeli government.

Iranian Foreign Minister Abbas Araghchi said Khamenei was alive “as far as I know.”

According to an unsourced report by Israel’s Channel 12, the operation involved the dropping of around 30 bombs on Khamenei’s compound. The report said Khamenei was underground at the time but not inside one of the two deepest bunkers, which it said only specialized U.S. munitions could penetrate. Satellite imagery circulating online appeared to show the compound largely destroyed.

Channel 12 also reported that Khamenei’s military secretary and unspecified members of his family were killed in the strike.

Israeli sources said the commander of the Islamic Revolutionary Guard Corps, Gen. Mohammad Pakpour, and Defense Minister Aziz Nasirzadeh were killed. President Masoud Pezeshkian was also targeted, along with senior intelligence officials.

Further reports said the Iranian army chief, Sayyid Abdolrahim Mousavi, was among those targeted, as was Ali Larijani, secretary of Iran’s Supreme National Security Council and viewed as a potential successor to Khamenei.

Ali Shamkhani, a former IRGC Navy commander and former army chief, was also targeted and, according to unconfirmed reports by Iran International, killed. Israel had previously targeted him during last June’s conflict and initially believed it had succeeded in killing him.

Other reported targets included Esmail Qaani, head of the IRGC’s Quds Force, and Majid Mousavi, chief of the IRGC’s Air Force, which oversees Iran’s ballistic missile program.

Channel 12 described the scale of the operation as unprecedented, reporting — possibly hyperbolically — that “30 were targeted in 30 seconds.”

Israel’s Kan public broadcaster reported that cabinet ministers had been informed the joint U.S.-Israeli campaign is expected to last about a week.