Source: Healthline
Security & Justice
Southern Lebanon Endures Massive Damage: 40,000 Homes Leveled Across 37 Towns
Israeli forces have systematically destroyed entire neighborhoods in southern Lebanon, leveling more than 37 towns and wiping out over 40,000 residential units, according to Lebanon's National News Agency.
Tuesday, November 5, 2024
Gaps in Coastal Radar Enabled Israeli Raid in Batroun, Army Commander Says
Lebanon’s army chief, General Joseph Aoun, detailed to Caretaker Prime Minister Najib Mikati how Israeli forces likely exploited gaps in the country's coastal radar system during the recent raid carried out in Batroun. The briefing comes as Lebanese officials seek answers on how Israel’s elite Shayetet 13 unit carried out the landing undetected.
Monday, November 4, 2024
Opinion
The Emptying of Baalbek Is a Moment to Take Stock
“Large numbers of people continue to flee their homes every day, as Israel’s military operations in Lebanon have been going on unabated.” These disturbing words could be from almost any news report about Israel’s invasion of its northern neighbour over the past month. However, they can be found in a report by the Norwegian Refugee Council’s Internal Displacement Monitoring Centre issued on July 27, 2006.
Saturday, November 2, 2024
A Future Without Hezbollah
At the end of September, when Israel’s campaign to destroy Hezbollah was reaching its height, I met one of the group’s supporters in a seaside café in western Beirut. He was a middle-aged man with a thin white beard and the spent look of someone who had not slept for days. He was an academic of sorts, not a fighter, but his ties to Hezbollah were deep and long-standing.
Thursday, October 31, 2024
Sports
Tottenham Forward Son Heung-min Crowned Asia’s International Player of the Year
Tottenham forward Son Heung-min was crowned as Asia’s International Player of the Year for the fourth time by the Asian Football Confederation at its annual awards ceremony Tuesday.
Wednesday, October 30, 2024
Real Madrid Launch Investigation into Racist Insults After El Clasico Defeat
Real Madrid has launched an investigation into racist insults directed at players during Saturday’s 4-0 home loss to Barcelona in LaLiga, it said on Sunday.
Monday, October 28, 2024
Monday 12 February 2024 14:52:37
Malfunctioning Immune Cells May Cause Type 2 Diabetes in Obesity
According to the World Health Organization (WHO)Trusted Source, the number of people with obesity worldwide has tripled in the past 50 years. While the United States and EuropeTrusted Source top the scale, Southeast Asian and African countries are fast catching up.
People with obesity have a body mass indexTrusted Source (BMI) of more than 30, although it must be remembered that BMI alone cannot determine whether that mass is made up of muscle or fatty tissue.
More usefully, the WHO defines obesityTrusted Source as “abnormal or excessive fat accumulation that presents a health risk” together with a BMI of more than 30.
Obesity increases the risk Source of several health conditions, which include:
- high blood pressure
- high LDL (“bad”) cholesterol, low HDL (“good”) cholesterol, and high triglycerides
- sleep apnea and breathing problems
- coronary heart disease
- stroke
- some cancers
- type 2 diabetes.
However, many people with obesity will not develop these conditions, and scientists at the University of Gothenburg, Sweden, may have found a reason why some are more likely to progress to metabolic disorders than others.
Why do only some people with obesity develop diabetes?
In a mouse study, the researchers found that, in some people, adipose tissue disrupts the function of white blood cells called macrophages, preventing them from cleaning up fragments of collagen.
This may lead to inflammation, increasing the likelihood of type 2 diabetes.
The study is published in PNAS.
Sebnem Unluisler, genetic engineer at the London Regenerative Institute, not involved in this research, commented to Medical News Today:
High-fat diet leads to collagen breakdown
Previous researchTrusted Source found that excess adipose, or fatty, tissue can lead to activation of immune cells that cause inflammation and lead to insulin resistance.
For this study, the researchers placed 7-week-old mice on a high-fat diet for 1 week, which resulted in a significant gain in adipose tissue compared with control mice fed a regular diet.
In the mice on the high-fat diet, more collagen type 1 was broken down into fragments, and macrophage numbers in the adipose tissue increased. These macrophages cleared the collagen fragments.
However, in high-fat diet-induced obese insulin-resistant male mice, the macrophages were unable to clear the fragments and instead caused an inflammatory reaction.
The researchers conclude that collagen fragments are not inert metabolites and solely markers of tissue remodeling, but change the microenvironment within the adipose tissue.
Dysfunctional adipose tissue leads to insulin resistance
Prof. Ingrid Wernstedt Asterholm, corresponding author and research leader in the Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden, told MNT:
“Dysfunctional adipose tissue cannot effectively store excess nutrients which then leads to deleterious fat deposition in, for example, the liver […] this will then lead to systemic insulin resistance that eventually can cause metabolic disorders such as type-2 diabetes,” she continued.
The researchers saw similar effects in vitro when they treated human macrophages with palmitate, high glucose, and high insulin to mimic conditions that lead to obesity.
Prof. Wernstedt Asterholm told us: “We show that human macrophages have similar function and regulation. Our current research focuses on translating our mouse findings to the human setting and it looks promising so far. I would also like to see whether and how this macrophage-collagen axis plays a role in other tissues such as in the heart.”
Potential for diabetes diagnosis and treatment
“Dysregulation of adipose tissue function, characterized by altered collagen turnover and macrophage activity, has been implicated in the pathogenesis of metabolic diseases. Understanding the specific cellular and molecular mechanisms involved could lead to novel therapeutic strategies for managing these conditions,” Unluisler told us.
Although the researchers behind this study found that isolated human cells reacted in a similar way to mouse cells, Unluisler said that she would like to see further research to confirm that similar adipose dysfunction occurs in people.
“While findings from animal studies can give us valuable insights, we need to be cautious when applying them to humans. Mice and humans have similarities, but also differences that might affect how findings translate. Further research with human subjects is necessary to confirm these results,” she told MNT.
The researchers are planning more research into both the treatment and diagnosis of type 2 diabetes, as Prof. Asterholm noted:
“Hopefully we will identify a macrophage target that can be used for developing better therapeutics..but in a more near future one could imagine that certain collagen fragments from adipose tissue end up in the circulation and thereby can be used as biomarkers to identify individuals that are at higher risk for developing type 2 diabetes.”
So, it is early days, but this study adds to the evidence that obesity may lead to adipose tissue dysfunction and metabolic diseases and offers an explanation for why this might happen. It could help identify those at greater risk of type 2 diabetes and even help the development of more effective therapies
