Source: Medical News Today
Security & Justice
Southern Lebanon Endures Massive Damage: 40,000 Homes Leveled Across 37 Towns
Israeli forces have systematically destroyed entire neighborhoods in southern Lebanon, leveling more than 37 towns and wiping out over 40,000 residential units, according to Lebanon's National News Agency.
Tuesday, November 5, 2024
Gaps in Coastal Radar Enabled Israeli Raid in Batroun, Army Commander Says
Lebanon’s army chief, General Joseph Aoun, detailed to Caretaker Prime Minister Najib Mikati how Israeli forces likely exploited gaps in the country's coastal radar system during the recent raid carried out in Batroun. The briefing comes as Lebanese officials seek answers on how Israel’s elite Shayetet 13 unit carried out the landing undetected.
Monday, November 4, 2024
Opinion
The Emptying of Baalbek Is a Moment to Take Stock
“Large numbers of people continue to flee their homes every day, as Israel’s military operations in Lebanon have been going on unabated.” These disturbing words could be from almost any news report about Israel’s invasion of its northern neighbour over the past month. However, they can be found in a report by the Norwegian Refugee Council’s Internal Displacement Monitoring Centre issued on July 27, 2006.
Saturday, November 2, 2024
A Future Without Hezbollah
At the end of September, when Israel’s campaign to destroy Hezbollah was reaching its height, I met one of the group’s supporters in a seaside café in western Beirut. He was a middle-aged man with a thin white beard and the spent look of someone who had not slept for days. He was an academic of sorts, not a fighter, but his ties to Hezbollah were deep and long-standing.
Thursday, October 31, 2024
Sports
Tottenham Forward Son Heung-min Crowned Asia’s International Player of the Year
Tottenham forward Son Heung-min was crowned as Asia’s International Player of the Year for the fourth time by the Asian Football Confederation at its annual awards ceremony Tuesday.
Wednesday, October 30, 2024
Real Madrid Launch Investigation into Racist Insults After El Clasico Defeat
Real Madrid has launched an investigation into racist insults directed at players during Saturday’s 4-0 home loss to Barcelona in LaLiga, it said on Sunday.
Monday, October 28, 2024
Friday 19 January 2024 18:56:50
Could Cutting Calories Help Slow Brain Aging?
As we get older, our body — including our brain — naturally begins to age. Certain tasks that the brain performs, such as memory and learningTrusted Source, begin to decline.
According to the National Institute on AgingTrusted Source, previous research shows that living a healthy lifestyle that includes physical activity, stress management, fostering social connections, and eating right, can help slow brain aging.
Now researchers from the Buck Institute for Research on Aging in Novato, CA, have found that restricting the amount of food a person eats may also help protect the brain from aging, via models of both fruit flies and human cells.
The research — recently published in the journal Nature CommunicationsTrusted Source — identified a specific gene that is enhanced through calorie restriction, aiding processes necessary for healthy brain aging.
How calorie restriction affects brain aging
According to Dr. Lisa Ellerby, professor at the Buck Institute for Research on Aging, adjunct professor of gerontology at the USC Leonard Davis School of Gerontology, and co-senior author of this study, the team decided to study the impact of calorie restriction on brain aging because dietary restriction is a significant intervention for the aging process and the brain is a particularly vulnerable organ during aging.
“Therefore, understanding factors that are modulated by dietary restriction and are protective in the brain is a significant research direction in the field,” Dr. Ellerby told Medical News Today. “Plus, many people are doing various forms of caloric restriction, in particular, intermittent fasting. This was a beginning step in understanding how those efforts might impact brain aging.”
For example, a review of research published in February 2021 reported that dietary restriction may help protect the brain against neuroinflammation and neurodegenerationTrusted Source.
“Age-related disease is arguably the greatest biomedical challenge in the 21st century,” Dr. Ellerby said.
Identifying the gene affected by calorie restriction
For this study, Dr. Ellerby and her team used both fruit fly models and human cells to examine how calorie restriction might affect how the brain ages.
The team used a fruit fly model of 160 different fly strains with different genetic backgrounds. Flies were either raised on a normal diet or a diet that was only 10% of its normal nutrition.
From there, researchers identified five genes that had specific variants that significantly impacted longevity under dietary restriction.
One of those is the “mustard” gene in fruit flies that correlates to the oxidation resistance 1 (OXR1) geneTrusted Source in humans and rodents.
Previous research shows that a depletionTrusted Source of OXR1 gene products is a shared feature of neurodegenerative conditions like Parkinson’s disease and diabetic retinopathy, while studies in mice show that overexpression of OXR1 may be protectiveTrusted Source against amyotrophic lateral
sclerosis (ALS).
The role of protein ‘recycling’ in aging
Additionally, scientists found the OXR1 gene affects the retromerTrusted Source, which sorts proteins and decides which can be reused by the body and which cannot.
“Recycling is important in our daily life,” Dr. Ellerby explained. “A cell does a similar process — it needs to recycle damaged components. The retromer is a cellular complex known to recycle proteins and lipids.”
“It was surprising [that] a protein known as OXR1 [expressed by the OXR1 gene] is involved in the retromer function,” she continued. “In past research, this protein was thought to be involved in responding to oxidative stressTrusted Source or detoxification.”
Dr. Ellerby said she and her colleagues believe these findings may be used in the future to help identify potential therapeutic targets to potentially slow aging and age-related neurodegenerative diseases.
“Finding factors that make the brain resilient or prevent the aging process will be important to slowing aging,” she continued. “It is possible that simple changes in our diet can increase the levels of OXR1 in the brain and this would be protective.”
“We boosted OXR1 in the flies via genetic manipulation,” Dr. Ellerby added. “We are planning to identify small molecules that increase the expression of OXR1 to design a therapeutic for the aging brain.”
Further studies should assess link between diet and brain aging
MNT also spoke with Dr. Clifford Segil, a neurologist at Providence Saint John’s Health Center in Santa Monica, CA, about this study.
After reading this research, Dr. Segil commented that it remains challenging to elucidate which findings can translate into providing neurologists with something to advise their patients to do to promote healthy eating.
“Dietary restriction was noted to have clear mechanisms of action with enhanced metabolism and fat burning with age and dietary restriction in the brain is something that should be pursued in more complicated organisms than fruit flies and yeast, though the research has to start in these simple organisms,” he explained.
“Dietary and caloric restriction, I believe, are worthy of further studies to determine if our excessive cultural caloric intake provides us with more harm than benefits. A healthy diet decreases the [chances] of having a stroke or cerebrovascular disease also,” added Dr. Segil.
He further pointed out that, with the current trend of injectable medications being used on a widespread basis for weight loss, large numbers of people are going to be effectively diet-restricted.
“This cohort may be an excellent group to use as data in future research to determine what dietary restriction can do to help avoid neurodegenerative diseases like Alzheimer’s or Parkinson’s disease,” he added.
“I would like a bench [of] scientists to take the results from this study and use it in more complicated organisms than fruit flies and yeasts. I would like to see this group of scientists collaborate with another group of scientists who could use human patients using injectable weight loss medications — GLP-1 agentsTrusted Source — to design a study with human clinical data,” said Dr. Segil.
