A high school student has stabbed a Spanish teacher to death in a school in the French town of Saint-Jean-de-Luz.

French government spokesperson Olivier Véran confirmed Wednesday's attack and said the perpetrator was 16 years old.

Police attended Saint-Thomas d'Aquin school with the local prosecutor, where the student was arrested.

French newspaper Sud Ouest said the attacker entered the classroom while the Spanish teacher was giving a class and attacked her.

The teacher was in her fifties and died of cardiac arrest after emergency services arrived at the school, local media reported.

France's Education Minister, Pap Ndiaye said in a tweet that his thoughts were with the teacher's "family, colleagues and pupils".

He said he was on his way to the school "straight away".

Local media reported the student may have been suffering from mental health issues. They said at this at this stage of the investigation there was no suggestion the incident was terror related.

Mr Véran said in a press conference the government would support educators across the country in the wake of the incident.

"I can hardly imagine the trauma that this represents," he said.