Top executives at two of the biggest Covid-19 vaccine manufacturers are split over how necessary a fourth dose is for most of the world’s population. 

 

Pfizer Inc. Chief Executive Officer Albert Bourla said in a CBS interview on Sunday that protection from three shots will wane and a fourth dose is needed “right now”. Then, in an interview, Moderna Inc. President Stephen Hoge said a second booster is probably only necessary for older people or those who are immunocompromised, with the rest of the public able to be more selective about receiving the shot, Business Insider reported Monday.

 

Both men agreed that the virus is here to stay.

Many countries are grappling with balancing living with Covid-19, dealing with a virus-weary or sometimes vaccine-hesitant public, and trying to thwart surges in severe cases that risk overwhelming health-care resources again.

 

Research suggests booster shots help reduce the consequences of an infection, though some vaccines work better than others in preventing infections caused by the omicron variant.

 

A fourth dose of the Pfizer-BioNTech vaccine was insufficient to prevent infection with omicron, though it gave a partial defense against the strain, according to preliminary data from a trial in Israel released in January. The country, along with South Korea, is one of the few to be giving fourth doses and so far only for the most vulnerable. 

Vaccine makers also face the likelihood of more variants emerging as the virus mutates.

 

Bourla said in an interview with Bloomberg News last week that Pfizer will soon submit data to U.S. regulators on the effects of a fourth dose of its Covid-19 vaccine, and he’s optimistic about developing a vaccine that would target omicron along with earlier variants.